\u3053\u308c\u3089\u306e\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u3001\u6574\u4f53\u3067\u306f\u624b\u6280\u306b\u3088\u308b\u7b4b\u8089\u306e\u7dca\u5f35\u7de9\u548c\u3001\u95a2\u7bc0\u306e\u52d5\u304d\u306e\u6539\u5584\u3001\u8840\u6db2\u5faa\u74b0\u306e\u4fc3\u9032\u3092\u56f3\u308a\u3001\u8eab\u4f53\u672c\u6765\u306e\u81ea\u7136\u6cbb\u7652\u529b\u3092\u5f15\u304d\u51fa\u3059\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u5f53\u9662\u3067\u306f\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u3068\u3044\u3046\u7279\u6b8a\u306a\u624b\u6280\u3092\u7528\u3044\u3066\u3001\u75c7\u72b6\u306e\u6839\u672c\u539f\u56e0\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u4e00\u822c\u7684\u306a\u6574\u4f53\u304c\u75c7\u72b6\u306e\u3042\u308b\u90e8\u4f4d\u306b\u7126\u70b9\u3092\u5f53\u3066\u308b\u306e\u306b\u5bfe\u3057\u3001\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u306f\u8eab\u4f53\u5168\u4f53\u3092\u4e00\u3064\u306e\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u6349\u3048\u3001\u771f\u306e\u539f\u56e0\u3092\u7279\u5b9a\u3057\u3066\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u884c\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u4f8b\u3048\u3070\u3001\u8170\u75db\u306e\u5834\u5408\u3001\u75db\u307f\u306e\u3042\u308b\u8170\u90e8\u3060\u3051\u3067\u306a\u304f\u3001\u9aa8\u76e4\u3001\u80a1\u95a2\u7bc0\u3001\u80f8\u90ed\u3001\u9838\u90e8\u307e\u3067\u5168\u8eab\u3092\u8a73\u7d30\u306b\u691c\u67fb\u3057\u3001\u8170\u75db\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u6839\u672c\u7684\u306a\u69cb\u9020\u7684\u30fb\u6a5f\u80fd\u7684\u7570\u5e38\u3092\u7279\u5b9a\u3057\u307e\u3059\u3002\u591a\u304f\u306e\u5834\u5408\u3001\u8170\u75db\u306e\u539f\u56e0\u306f\u8170\u4ee5\u5916\u306e\u90e8\u4f4d\u306b\u3042\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u4e00\u6642\u7684\u306a\u75c7\u72b6\u306e\u7de9\u548c\u3067\u306f\u306a\u304f\u3001\u9577\u671f\u7684\u306a\u6539\u5584\u3068\u518d\u767a\u9632\u6b62\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u306e\u52b9\u679c\u306f\u3001\u591a\u6570\u306e\u56fd\u969b\u7684\u306a\u7814\u7a76\u306b\u3088\u308a\u79d1\u5b66\u7684\u306b\u8a3c\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n 2022\u5e74\u306bBMJ Open\u8a8c\u306b\u767a\u8868\u3055\u308c\u305f\u5927\u898f\u6a21\u306a\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u30013,740\u540d\u306e\u53c2\u52a0\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f55\u306e\u81e8\u5e8a\u8a66\u9a13\u304c\u5206\u6790\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n \u7814\u7a76\u7d50\u679c\u306b\u3088\u308b\u3068\u3001\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u624b\u6280\u7642\u6cd5\uff08OMT\uff09\u306f\u4ee5\u4e0b\u306e\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n\n\n\n \u3055\u3089\u306b\u30012025\u5e74\u306e\u6700\u65b0\u7814\u7a76\u3067\u306f\u3001\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u75db\u307f\u3001\u30d0\u30e9\u30f3\u30b9\u611f\u899a\u3001\u751f\u6d3b\u306e\u8cea\u306e\u6539\u5584\u306b\u3082\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u3053\u308c\u3089\u306e\u79d1\u5b66\u7684\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u304c\u5358\u306a\u308b\u4ee3\u66ff\u533b\u7642\u3067\u306f\u306a\u304f\u3001\u78ba\u7acb\u3055\u308c\u305f\u52b9\u679c\u7684\u306a\u65bd\u8853\u6cd5\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u5f53\u9662\u3067\u306f\u3001\u30d5\u30e9\u30f3\u30b9\u3067\u958b\u767a\u3055\u308c\u305f\u6700\u5148\u7aef\u306eLMO\uff08\u30e1\u30ab\u30cb\u30ab\u30eb\u30ea\u30f3\u30af\u30fb\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\uff09\u6280\u8853\u3092\u5c0e\u5165\u3057\u3001\u4ed6\u9662\u3067\u306f\u5b9f\u73fe\u3067\u304d\u306a\u3044\u7cbe\u5bc6\u306a\u8a3a\u65ad\u3068\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n LMO\u306f1970\u5e74\u4ee3\u5f8c\u534a\u306b\u30d5\u30e9\u30f3\u30b9\u306e\u30aa\u30b9\u30c6\u30aa\u30d1\u30b9\u3001\u30dd\u30fc\u30eb\u30fb\u30b7\u30e7\u30d5\u30fc\u30eb\u306b\u3088\u308a\u958b\u767a\u3055\u308c\u305f\u9769\u65b0\u7684\u306a\u8a3a\u65ad\u30fb\u65bd\u8853\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002\u5f93\u6765\u306e\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u3068\u306f\u7570\u306a\u308a\u3001\u8eab\u4f53\u5168\u4f53\u306e400\u7b87\u6240\u3092\u7cfb\u7d71\u7684\u306b\u691c\u67fb\u3057\u3001\u6700\u3082\u8eab\u4f53\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u539f\u767a\u6027\u306e\u6a5f\u80fd\u969c\u5bb3\u3092\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n LMO\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u30d7\u30ed\u30bb\u30b9\uff1a<\/p>\n\n\n\n \u3053\u306e\u624b\u6cd5\u306b\u3088\u308a\u3001\u75c7\u72b6\u304b\u3089\u9060\u304f\u96e2\u308c\u305f\u90e8\u4f4d\u306b\u3042\u308b\u771f\u306e\u539f\u56e0\u3092\u767a\u898b\u3057\u3001\u9023\u9396\u7684\u306b\u8eab\u4f53\u5168\u4f53\u306e\u6a5f\u80fd\u306e\u6b63\u5e38\u5316\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n LMO\u306f\u5f93\u6765\u306e\u65bd\u8853\u6cd5\u3068\u306f\u4e00\u7dda\u3092\u753b\u3059\u7cbe\u5bc6\u6027\u3068\u52b9\u679c\u6027\u3092\u6709\u3057\u3001\u3088\u308a\u7684\u78ba\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u6839\u672c\u7684\u306a\u6539\u5584\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u6574\u4f53\u9662\u9078\u3073\u3067\u306f\u3001\u65bd\u8853\u8005\u306e\u8cc7\u683c\u3068\u7d4c\u9a13\u3001\u4f7f\u7528\u3059\u308b\u6280\u8853\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3001\u305d\u3057\u3066\u500b\u5225\u5bfe\u5fdc\u306e\u8cea\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n \u57ce\u6771\u533a\u306b\u306f\u591a\u304f\u306e\u6574\u4f53\u9662\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u65bd\u8853\u52b9\u679c\u3068\u5b89\u5168\u6027\u306b\u306f\u5927\u304d\u306a\u5dee\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u9078\u629e\u3059\u3079\u304d\u6574\u4f53\u9662\u306e\u7279\u5fb4\uff1a<\/p>\n\n\n\n \u907f\u3051\u308b\u3079\u304d\u6574\u4f53\u9662\u306e\u7279\u5fb4\uff1a<\/p>\n\n\n\n \u9069\u5207\u306a\u6574\u4f53\u9662\u9078\u3073\u306b\u3088\u308a\u3001\u5b89\u5168\u3067\u52b9\u679c\u7684\u306a\u65bd\u8853\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u75c7\u72b6\u306e\u6839\u672c\u7684\u6539\u5584\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n \u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u6574\u4f53\u9662\u30c8\u30e9\u30b9\u30c8\u306f\u3001\u9ad8\u3044\u5c02\u9580\u6027\u3068\u79d1\u5b66\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u57ce\u6771\u533a\u3067\u591a\u304f\u306e\u30af\u30e9\u30a4\u30a2\u30f3\u30c8\u69d8\u304b\u3089\u4fe1\u983c\u3092\u3044\u305f\u3060\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u5f53\u9662\u306e\u5f37\u307f\u306f\u4ee5\u4e0b\u306e4\u70b9\u3067\u3059\uff1a<\/p>\n\n\n\n \u5f53\u9662\u3067\u306e\u65bd\u8853\u306e\u6d41\u308c\uff1a<\/p>\n\n\n\n \u3053\u306e\u3088\u3046\u306a\u79d1\u5b66\u7684\u3067\u4f53\u7cfb\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u591a\u304f\u306e\u30af\u30e9\u30a4\u30a2\u30f3\u30c8\u69d8\u304c\u75c7\u72b6\u306e\u6839\u672c\u7684\u6539\u5584\u3092\u5b9f\u611f\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u5f53\u9662\u3067\u306f\u3001\u57ce\u6771\u533a\u306e\u7686\u69d8\u304c\u62b1\u3048\u308b\u69d8\u3005\u306a\u75c7\u72b6\u306b\u5bfe\u3057\u3066\u3001\u6839\u672c\u539f\u56e0\u306b\u57fa\u3065\u3044\u305f\u52b9\u679c\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n \u591a\u304f\u306e\u75c7\u72b6\u306f\u76f8\u4e92\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u5c40\u6240\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u306f\u9650\u754c\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u6162\u6027\u8170\u75db\u306e\u5834\u5408<\/strong>\uff1a \u6d77\u5916\u7814\u7a76\u3067\u306f\u3001\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u624b\u6280\u7642\u6cd5\u306b\u3088\u308a\u6162\u6027\u8170\u75db\u60a3\u8005\u306e\u75db\u307f\u304c\u5e73\u574740%\u6e1b\u5c11\u3057\u3001\u6a5f\u80fd\u6539\u5584\u3082\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u9662\u306eLMO\u6280\u8853\u3067\u306f\u3001\u8170\u75db\u306e\u539f\u56e0\u3068\u306a\u308b\u9aa8\u76e4\u306e\u6b6a\u307f\u3001\u80f8\u90ed\u306e\u5236\u9650\u3001\u5185\u81d3\u306e\u6a5f\u80fd\u969c\u5bb3\u307e\u3067\u5305\u62ec\u7684\u306b\u8a55\u4fa1\u30fb\u30a2\u30d7\u30ed\u30fc\u30c1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u80a9\u3053\u308a\u30fb\u9838\u90e8\u75db\u306e\u5834\u5408<\/strong>\uff1a \u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306b\u3088\u308b\u3068\u3001\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u624b\u6280\u7642\u6cd5\u306f\u9838\u90e8\u75db\u306b\u5bfe\u3057\u3066\u6709\u610f\u306a\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u3001\u9838\u690e\u3060\u3051\u3067\u306a\u304f\u3001\u80f8\u90ed\u3001\u808b\u9aa8\u3001\u5185\u81d3\u7cfb\u306e\u5236\u9650\u3082\u8a55\u4fa1\u3057\u3001\u6839\u672c\u7684\u306a\u6539\u5584\u3092\u56f3\u308a\u307e\u3059\u3002<\/p>\n\n\n\n \u982d\u75db\u306e\u5834\u5408<\/strong>\uff1a \u7dca\u5f35\u578b\u982d\u75db\u3084\u7247\u982d\u75db\u306b\u5bfe\u3059\u308b\u30aa\u30b9\u30c6\u30aa\u30d1\u30b7\u30fc\u306e\u52b9\u679c\u3082\u7814\u7a76\u3067\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5f53\u9662\u3067\u306f\u3001\u982d\u84cb\u9aa8\u3001\u9838\u690e\u3001\u80f8\u90ed\u306e\u52d5\u8108\u7cfb\u306e\u5236\u9650\u3092\u8a73\u7d30\u306b\u8a55\u4fa1\u3057\u3001\u8840\u6d41\u6539\u5584\u3068\u795e\u7d4c\u7cfb\u306e\u6b63\u5e38\u5316\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u75c7\u72b6\u5225\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u306f\u306a\u304f\u3001\u500b\u4eba\u306e\u8eab\u4f53\u5168\u4f53\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u8003\u616e\u3057\u305f\u65bd\u8853\u306b\u3088\u308a\u3001\u3088\u308a\u52b9\u679c\u7684\u3067\u6301\u7d9a\u7684\u306a\u6539\u5584\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n \u5f53\u9662\u3067\u306f\u3001\u30af\u30e9\u30a4\u30a2\u30f3\u30c8\u69d8\u306e\u7d4c\u6e08\u7684\u8ca0\u62c5\u3092\u8003\u616e\u3057\u306a\u304c\u3089\u3001\u6700\u9069\u306a\u65bd\u8853\u30d7\u30e9\u30f3\u3092\u3054\u63d0\u6848\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n LMO\u306e\u7279\u5fb4\u3067\u3042\u308b\u9ad8\u3044\u7cbe\u5bc6\u6027\u306b\u3088\u308a\u3001\u7684\u78ba\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u52b9\u7387\u7684\u306a\u6539\u5584\u3092\u76ee\u6307\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n HP\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u5f53\u9662\u306e\u65bd\u8853\u65b9\u91dd\uff1a<\/p>\n\n\n\n \u52b9\u7387\u7684\u306a\u65bd\u8853\u306b\u3088\u308a\u3001\u6642\u9593\u7684\u30fb\u7d4c\u6e08\u7684\u8ca0\u62c5\u3092\u6700\u5c0f\u9650\u306b\u6291\u3048\u306a\u304c\u3089\u3001\u6700\u5927\u306e\u65bd\u8853\u52b9\u679c\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u25c6\u76e3\u4fee<\/strong> 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